Opportunity Information: Apply for RFA MH 27 205
The National Institute of Mental Health (NIMH), part of the National Institutes of Health (NIH), is planning a single source cooperative agreement to continue support for the Accelerating Medicines Partnership for Schizophrenia (AMP SCZ) Data Processing, Analysis, and Coordination Center (DPACC). The purpose of this award is to enable DPACC to finish the processing and analysis of longitudinal, multi-modal biomarker and clinical outcome data that were collected over a 24-month period. In practice, this means the funded center is expected to carry the work across the finish line on a large, complex dataset that combines multiple types of measures (for example, different biological signals and clinical outcomes) tracked over time, with a focus on producing analyzable, high-quality outputs and coordinated deliverables that can support schizophrenia research and related therapeutic development efforts.
This opportunity is being issued as a Notice of Funding Opportunity (NOFO) with a single source restriction, meaning NIH intends to invite an application from only one eligible organization. Although it is single source, the application will still go through NIH’s standard peer-review process, and funding will only be provided if the application is considered meritorious. The award mechanism is a U24 cooperative agreement, which generally indicates substantial programmatic involvement by NIH staff during the project, emphasizing coordination, milestone-driven progress, and close collaboration between the funded awardee and the federal sponsor. The NOFO is explicitly labeled “Clinical Trial Not Allowed,” so the work supported under this award is intended to focus on data processing, analysis, and coordination activities rather than initiating or running a clinical trial.
Eligibility is tightly limited: only Brigham and Women’s Hospital is eligible to apply. No other domestic institutions may apply under this NOFO, and foreign participation is restricted as well. Non-U.S. entities are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components (as defined under the NIH Grants Policy Statement) are not allowed. This structure reinforces that the award is meant as a continuation of an existing, specific DPACC effort rather than an open competition for new centers.
Key administrative details included in the announcement are as follows: the funding opportunity title is “Single Source: Accelerating Medicines Partnership Schizophrenia (AMP SCZ): Data Processing, Analysis, and Coordination Center (DPACC) (U24 Clinical Trial Not Allowed).” The funding opportunity number is RFA-MH-27-205, with NIMH as the sponsoring institute. It is categorized as discretionary funding, using the cooperative agreement instrument, and sits within the health funding activity category (CFDA 93.242). NIH anticipates making one award, with an award ceiling of $5,000,000. The opportunity was created on 2026-05-07, and the original closing date is 2026-06-09.Apply for RFA MH 27 205
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Single Source: Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Data Processing, Analysis, and Coordination Center (DPACC) (U24 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242.
- This funding opportunity was created on 2026-05-07.
- Applicants must submit their applications by 2026-06-09. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $5,000,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Others.
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Frequently Asked Questions (FAQs)
What is this funding opportunity?
This is a Notice of Funding Opportunity (NOFO) from the National Institute of Mental Health (NIMH), part of the National Institutes of Health (NIH), to continue support for the Accelerating Medicines Partnership for Schizophrenia (AMP SCZ) Data Processing, Analysis, and Coordination Center (DPACC). The NOFO title is: "Single Source: Accelerating Medicines Partnership Schizophrenia (AMP SCZ): Data Processing, Analysis, and Coordination Center (DPACC) (U24 Clinical Trial Not Allowed)."
What is the main purpose of the award?
The purpose is to enable DPACC to complete the processing and analysis of longitudinal, multi-modal biomarker and clinical outcome data collected over a 24-month period. The intent is to carry an existing, large and complex dataset across the finish line by producing analyzable, high-quality outputs and coordinated deliverables that support schizophrenia research and related therapeutic development efforts.
What type of data is involved in this project?
The project focuses on a longitudinal dataset collected over 24 months that combines multi-modal biomarker measures and clinical outcome data. In practical terms, it is a multi-measure, over-time dataset intended to yield high-quality, analyzable outputs for schizophrenia research.
What activities are expected to be supported under this award?
The award is intended to support data processing, data analysis, and coordination activities for AMP SCZ DPACC, with an emphasis on producing high-quality outputs and coordinated deliverables from the existing dataset.
Are clinical trials allowed under this NOFO?
No. The NOFO is explicitly labeled "Clinical Trial Not Allowed," indicating the supported work is focused on processing, analysis, and coordination rather than initiating or conducting a clinical trial.
What is the funding mechanism for this opportunity?
The funding mechanism is a U24 cooperative agreement. A cooperative agreement generally indicates substantial programmatic involvement by NIH staff and emphasizes coordination, milestone-driven progress, and close collaboration between the awardee and the federal sponsor.
What does "cooperative agreement" imply for how the project will be run?
Because this is a U24 cooperative agreement, NIH staff are expected to have substantial programmatic involvement during the project. The NOFO describes this as involving coordination, milestone-driven progress, and close collaboration between the funded center and NIH.
Is this an open competition?
No. This NOFO includes a single source restriction, meaning NIH intends to invite an application from only one eligible organization.
Who is eligible to apply?
Eligibility is limited to Brigham and Women's Hospital. No other domestic institutions may apply under this NOFO.
Can foreign organizations apply?
No. Non-U.S. entities are not eligible to apply under this NOFO.
Are foreign components permitted as part of a U.S. organization?
No. Non-U.S. components of U.S. organizations are not eligible, and foreign components (as defined under the NIH Grants Policy Statement) are not allowed.
Does a single source NOFO still go through peer review?
Yes. Even though the NOFO is single source, the application will still go through NIH's standard peer-review process.
Is funding guaranteed because it is single source?
No. The announcement states that funding will only be provided if the application is considered meritorious through NIH's standard review process.
How many awards does NIH expect to make?
NIH anticipates making one award.
What is the maximum funding level for this opportunity?
The award ceiling is $5,000,000.
Which NIH institute is sponsoring this NOFO?
The sponsoring institute is the National Institute of Mental Health (NIMH).
What is the NOFO number?
The funding opportunity number is RFA-MH-27-205.
What is the CFDA/assistance listing number and funding category?
The opportunity is in the health funding activity category and is associated with CFDA 93.242. It is described as discretionary funding using the cooperative agreement instrument.
When was this opportunity created?
The opportunity was created on 2026-05-07.
What is the closing date for applications?
The original closing date is 2026-06-09.
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