Opportunity Information: Apply for RFA CE 25 025
This grant opportunity, titled "Rigorous Evaluation of Community- and Societal-Level Primary Prevention Approaches to Prevent Adverse Childhood Experiences (ACEs): Expanding the Best Available Evidence" (RFA CE 25 025), is a discretionary CDC funding announcement offered through a cooperative agreement. Its core aim is to fund investigator-initiated research that can produce strong, credible evidence about what actually works to prevent adverse childhood experiences before they happen. The emphasis is on primary prevention policies and programs that operate at the community or broader societal level, rather than solely focusing on individual or clinical interventions, and on approaches that directly confront the social and health inequities that make certain populations more likely to experience ACEs.
A central feature of the opportunity is that applicants are expected to rigorously evaluate prevention approaches that already exist in the real world. In practice, that means the policy or program should already be developed and either currently implemented or genuinely ready for implementation in the community or population the project will study. The CDC is specifically targeting approaches that have not yet been evaluated with rigorous outcome methods, or that are not already in the middle of a rigorous outcome evaluation. In other words, the money is meant to close evidence gaps by taking promising, on-the-ground strategies and testing them with high-quality evaluation designs so the field can move beyond theory and early signals into solid conclusions about outcomes and impact.
The funded research should align with the National Center for Injury Prevention and Control (NCIPC) ACEs Research Priorities and is intended to expand the "best available evidence" for preventing ACEs. Projects should fit within one or more of the strategy areas laid out in the CDC ACEs Prevention Resource for Action. The listed strategy areas for this announcement include: (1) Ensure a Strong Start for Children, which generally covers community-level efforts that support healthy early childhood development and stable caregiving environments; (2) Promote Social Norms That Protect Against Violence and Adversity, which typically involves shifting community standards, expectations, and behaviors in ways that reduce tolerance for violence and adversity and increase protective norms; and (3) Strengthen Economic Supports to Families, which focuses on policies or programs that reduce financial strain and material hardship, conditions that can increase stress and risk for family adversity. While the announcement does not prescribe specific interventions, it makes clear that the prevention approaches should be positioned to influence population-level or community-level conditions linked to ACE risk, especially where inequities are driving disproportionate harm.
Administratively, this is a CDC cooperative agreement, which usually implies a more collaborative relationship with the agency than a standard grant, often including technical input or partnership expectations consistent with CDC cooperative funding mechanisms. The opportunity sits in the health funding activity category under CFDA 93.136. The award ceiling is $450,000, and the CDC anticipates making 2 awards under this announcement, making it a relatively competitive program with a strong focus on methodological rigor and clear public health relevance. The original application closing date is December 2, 2024, and the opportunity was created on August 29, 2024.
Eligibility is broad and includes many types of applicants who are positioned to evaluate community or population approaches. Eligible applicants include state, county, and city/township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding higher education institutions in those nonprofit categories); for-profit organizations other than small businesses as well as small businesses; and other unrestricted entities. This wide eligibility pool suggests CDC is open to research teams led by universities, public agencies, community-based organizations, tribal entities, and private-sector partners, as long as the proposed study can deliver a rigorous outcome evaluation of an existing community- or societal-level primary prevention strategy and can speak directly to reducing ACE risk and inequities.
Overall, the opportunity is best understood as a targeted push to strengthen the national evidence base for preventing ACEs by funding real-world evaluations of policies and programs that shape the conditions families and children live in. The CDC is looking for studies that can credibly attribute changes in ACE-related outcomes to the intervention being evaluated, while also generating knowledge that can be translated into broader public health practice and policy, especially for communities facing elevated risk due to structural and social inequities.Apply for RFA CE 25 025
- The Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Rigorous Evaluation of Community- and Societal-Level Primary Prevention Approaches to Prevent Adverse Childhood Experiences (ACEs): Expanding the Best Available Evidence" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.136.
- This funding opportunity was created on 2024-08-29.
- Applicants must submit their applications by 2024-12-02. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $450,000.00 in funding.
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others, Unrestricted.
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Frequently Asked Questions (FAQs)
What is the title of this CDC funding opportunity?
The opportunity is titled "Rigorous Evaluation of Community- and Societal-Level Primary Prevention Approaches to Prevent Adverse Childhood Experiences (ACEs): Expanding the Best Available Evidence" (RFA CE 25 025).
What type of funding mechanism is this?
This is a discretionary CDC funding announcement offered through a cooperative agreement.
What is the main purpose of the grant?
The main purpose is to fund investigator-initiated research that produces strong, credible evidence about what works to prevent adverse childhood experiences (ACEs) before they happen, with a focus on primary prevention approaches at the community or broader societal level.
What does the announcement mean by "primary prevention" in this context?
In this announcement, primary prevention refers to preventing ACEs before they occur by addressing community-level or societal-level conditions that contribute to risk, rather than focusing only on responses after ACEs happen.
What kinds of approaches does CDC want applicants to evaluate?
CDC expects applicants to rigorously evaluate prevention policies and programs that already exist in the real world. The approach should already be developed and either currently implemented or genuinely ready for implementation in the population or community being studied.
Does the program fund development of brand-new interventions?
The emphasis is on evaluating existing real-world policies or programs that are already developed and implemented or ready to implement. The opportunity is framed around closing evidence gaps by testing promising on-the-ground strategies using rigorous outcome evaluation designs.
Are there restrictions on what has already been evaluated?
Yes. CDC is specifically targeting approaches that have not yet been evaluated with rigorous outcome methods, or approaches that are not already in the middle of a rigorous outcome evaluation.
What level of intervention is prioritized: individual/clinical or community/societal?
The announcement emphasizes community-level and broader societal-level primary prevention approaches, rather than interventions that are solely individual-level or clinical.
How does the opportunity address equity and inequities?
The opportunity emphasizes approaches that directly confront the social and health inequities that increase the likelihood certain populations will experience ACEs. Projects are expected to focus on community or population conditions linked to ACE risk, especially where inequities drive disproportionate harm.
What CDC priorities should the research align with?
Funded research should align with the National Center for Injury Prevention and Control (NCIPC) ACEs Research Priorities and is intended to expand the "best available evidence" for preventing ACEs.
What strategy areas are highlighted for this announcement?
Projects should fit within one or more strategy areas from the CDC ACEs Prevention Resource for Action. The strategy areas listed in this announcement include: (1) Ensure a Strong Start for Children, (2) Promote Social Norms That Protect Against Violence and Adversity, and (3) Strengthen Economic Supports to Families.
What does "Ensure a Strong Start for Children" generally cover?
It generally covers community-level efforts that support healthy early childhood development and stable caregiving environments.
What does "Promote Social Norms That Protect Against Violence and Adversity" generally involve?
It typically involves shifting community standards, expectations, and behaviors to reduce tolerance for violence and adversity and increase protective norms.
What does "Strengthen Economic Supports to Families" focus on?
It focuses on policies or programs that reduce financial strain and material hardship, which can increase stress and risk for family adversity.
Does CDC prescribe specific interventions that must be used?
No. The announcement does not prescribe specific interventions, but it makes clear that prevention approaches should be positioned to influence population-level or community-level conditions linked to ACE risk.
What makes this a cooperative agreement rather than a standard grant?
As a cooperative agreement, it typically implies a more collaborative relationship with CDC than a standard grant, often including technical input or partnership expectations consistent with CDC cooperative funding mechanisms.
What is the CFDA number (or assistance listing) associated with this opportunity?
The opportunity is listed under CFDA 93.136.
What is the maximum award amount (award ceiling)?
The award ceiling is $450,000.
How many awards does CDC expect to make?
CDC anticipates making 2 awards under this announcement.
When is the application due?
The original application closing date is December 2, 2024.
When was this funding opportunity created?
The opportunity was created on August 29, 2024.
Who is eligible to apply?
Eligibility is broad and includes: state, county, and city/township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding higher education institutions in those nonprofit categories); for-profit organizations other than small businesses as well as small businesses; and other unrestricted entities.
Can universities apply?
Yes. Public and state-controlled institutions of higher education and private institutions of higher education are listed as eligible applicants.
Can tribal governments and tribal organizations apply?
Yes. Federally recognized Native American tribal governments and other tribal organizations are included in the eligibility list.
Can nonprofits apply even if they do not have 501(c)(3) status?
Yes. Nonprofits with or without 501(c)(3) status are listed as eligible (with the note that the nonprofit categories exclude higher education institutions).
Can for-profit organizations or small businesses apply?
Yes. For-profit organizations other than small businesses, as well as small businesses, are included in the eligibility list.
What kind of research approach is CDC looking for?
CDC is looking for rigorous outcome evaluations that can credibly attribute changes in ACE-related outcomes to the policy or program being evaluated, strengthening conclusions about outcomes and impact.
What does it mean to "expand the best available evidence"?
It means generating stronger, more credible evidence about which community- or societal-level primary prevention approaches effectively prevent ACEs, especially by filling evidence gaps where rigorous outcome evaluations have not yet been conducted.
Is this opportunity focused on translating findings into practice and policy?
Yes. The opportunity highlights generating knowledge that can be translated into broader public health practice and policy, especially for communities facing elevated risk due to structural and social inequities.
How competitive is this opportunity likely to be?
It is likely to be competitive because CDC anticipates making only 2 awards and emphasizes strong methodological rigor and clear public health relevance.
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