Opportunity Information: Apply for RFA HD 21 025
The Maternal and Pediatrics Precision in Therapeutics Hub (MPRINT) (P30 Clinical Trial Not Allowed) funding opportunity (RFA-HD-21-025) is a National Institutes of Health (NIH), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) initiative to establish a single, national Knowledge and Research Coordination Center (KRCC) that serves as the operational and public-facing backbone of the broader MPRINT Hub. The overall purpose is to strengthen and coordinate therapeutics-focused research and knowledge development for obstetrics, lactation, and pediatrics, with an explicit emphasis on improving inclusion of people with disabilities. Rather than funding clinical trials, the award supports a central infrastructure that gathers expertise, organizes resources, and helps the field move toward more precise, evidence-driven use and development of therapeutics for pregnant and lactating people and children.
At the center of this FOA is the creation and management of a curated, accessible knowledge base focused on maternal and pediatric pharmacology and therapeutics. The KRCC is expected to aggregate and synthesize existing information and, just as importantly, highlight gaps where knowledge is limited or missing. The announcement specifically points to core scientific domains that inform drug development and regulatory science, including pharmacokinetics and pharmacodynamics as well as genetics, proteomics, and metabolomics. In practice, that means the KRCC is positioned to function like a national clearinghouse and coordination engine: bringing together data and insights across disciplines, standardizing how information is presented, and enabling researchers, regulators, and drug developers to quickly find what is known, what tools exist, and where additional work is needed.
A major deliverable is a web portal that provides access to the underlying knowledge base and related hub resources. This portal is intended to be the main entry point for the broader community, making the KRCC the public interface of MPRINT. Beyond simply hosting information, the KRCC is responsible for ensuring the hub operates smoothly, which includes coordinating communications, facilitating collaboration, supporting governance and working groups as needed, and maintaining consistent engagement with stakeholders across the research and therapeutics ecosystem. The KRCC also serves as a conduit to other MPRINT components, particularly the Centers of Excellence in Therapeutics (CETs), which are supported under a companion funding announcement (RFA-HD-21-026). In other words, while CETs contribute specialized capabilities and research expertise, the KRCC connects those pieces into a coherent national resource and makes the combined output usable to external audiences.
Another key feature is the management of an Opportunity Pool of funds designed to address emergent or time-sensitive needs that arise in support of national maternal and pediatric therapeutics research. This gives the hub flexibility to respond to new scientific questions, urgent coordination needs, or gaps that become apparent through the knowledge base and community engagement. The KRCC is expected to oversee this pool responsibly, aligning investments with the hub mission and ensuring that rapid-response activities complement, rather than duplicate, ongoing efforts.
From an administrative standpoint, this is a discretionary grant using the P30 center mechanism, with clinical trials not allowed under this FOA. The opportunity was created on August 3, 2020, with an original application due date of November 30, 2020, and it anticipated making a single award (ExpectedAwards: 1). The award ceiling is listed as 0, which typically indicates applicants should refer to the FOA for budgeting guidance rather than relying on a fixed maximum in the summary record. Eligibility is broad and includes various levels of government, public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), for-profit organizations (including small businesses), tribal governments and tribal organizations, and other entities as described in the full eligibility language. The program falls under CFDA 93.865 and sits within the NIH portfolio under the Department of Health and Human Services.
Taken together, the MPRINT KRCC opportunity is about building national-scale coordination and knowledge infrastructure for precision therapeutics in maternal and pediatric settings. The funded center is expected to make maternal and pediatric therapeutics knowledge easier to find, compare, and apply; to strengthen connections among researchers, regulators, and developers; to clarify where evidence is weak or missing; and to provide the operational leadership that keeps the entire MPRINT Hub functioning as a unified, accessible, and responsive national resource.Apply for RFA HD 21 025
- The Department of Health and Human Services, National Institutes of Health in the health, income security and social services sector is offering a public funding opportunity titled "Maternal and Pediatrics Precision in Therapeutics Hub (MPRINT) (P30 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865.
- This funding opportunity was created on Aug 03, 2020.
- Applicants must submit their applications by Nov 30, 2020. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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| Developmental Mechanisms of Human Structural Birth Defects (P01) Apply for RFA HD 17 017 Funding Number: RFA HD 17 017 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
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| Integrative Research in Gynecologic Health (R01) Apply for RFA HD 18 017 Funding Number: RFA HD 18 017 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $499,999 |
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