Opportunity Information: Apply for RFA HD 24 012
The HEAL Initiative: HEAL KIDS (Knowledge, Innovation and Discovery Studies) Pain Program Resource and Data Center (RDC) funding opportunity (RFA-HD-24-012) is an NIH cooperative agreement (U24; clinical trial not allowed) designed to establish one centralized coordinating hub to support the broader HEAL KIDS Pain research program. It sits under the NIH Helping to End Addiction Long-term (HEAL) Initiative and is led by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) along with other participating NIH Institutes and Centers. The core idea is that, rather than funding multiple separate data centers, NIH intends to make a single award to an RDC that can standardize, organize, and streamline how HEAL KIDS Pain studies collect, manage, harmonize, and share data and related resources across the entire program.
The RDC is expected to provide leadership and hands-on infrastructure for several tightly connected functions: data collection and management (including systems, workflows, and quality oversight), data curation (cleaning, documentation, and preparation for reuse), data harmonization (aligning variables and formats across different sites and studies), and the development and implementation of data standards (common data elements, naming conventions, metadata requirements, and consistent definitions). In addition to these technical data responsibilities, the RDC is also tasked with administrative and logistical coordination for HEAL KIDS Pain activities, including helping ensure compliance with NIH HEAL-related expectations and coordinating shared research-related resources that multiple projects will rely on. Because this is a U24 cooperative agreement, the NIH will have substantial involvement, meaning the RDC will be expected to work closely with NIH program staff and align deliverables, timelines, and governance with NIH direction.
This NOFO is designed to run in parallel with a companion opportunity (RFA-HD-24-011) that funds innovative, multi-site, large-scale clinical trials focused on acute pain in infants, children, and adolescents, including populations with disabilities and/or those experiencing health disparities. In practice, that means the RDC is meant to be the backbone that enables those clinical trial sites and other HEAL KIDS Pain research activities to operate on a shared set of data practices and tools, making it easier to combine information across studies, improve comparability, and accelerate secondary analyses. Even though the companion NOFO supports clinical trials, the RDC award itself is explicitly "clinical trial not allowed," signaling that the center should not be running interventional trials; instead, it should focus on enabling and coordinating the research ecosystem, especially on the data and resource side.
Eligibility is broad and includes many domestic U.S. organization types: state, county, and local governments; special district governments; independent school districts; public and private institutions of higher education; federally recognized tribal governments; tribal organizations other than federally recognized governments; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); small businesses; and other eligible entities. The announcement also calls out additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, Indian/Native American tribal governments other than federally recognized entities (as applicable), and U.S. territories or possessions. At the same time, the NOFO clearly limits foreign involvement: non-domestic (non-U.S.) entities (foreign organizations/institutions) are not eligible to apply; non-domestic components of U.S. organizations are not eligible to apply; and foreign components, as NIH defines them in the NIH Grants Policy Statement, are not allowed.
Administratively, the sponsoring agency is the National Institutes of Health, and the opportunity is categorized under discretionary funding, using the cooperative agreement mechanism to reflect NIH's active partnership role. The original closing date listed is 2023-11-20. The opportunity references multiple CFDA numbers associated with NIH programs (93.121, 93.213, 93.233, 93.273, 93.361, 93.837, 93.838, 93.839, 93.840, 93.846, 93.853, 93.865, 93.866), reflecting the multi-institute nature of HEAL-related funding streams. The award ceiling and expected number of awards are not specified in the provided source text, but the narrative states NIH intends to fund a single RDC, emphasizing that this is meant to be one central, program-wide resource rather than multiple competing centers.
Taken together, the RDC opportunity is essentially a program infrastructure award: it is meant to create the shared data environment, rules, coordination processes, and operational support that allow HEAL KIDS Pain studies, including the companion multi-site clinical trials, to generate consistent, high-quality, reusable data. The expected impact is improved standardization and interoperability across pediatric pain research efforts within HEAL, faster cross-study learning, reduced duplication of effort at individual sites, and stronger compliance with HEAL and NIH data expectations.Apply for RFA HD 24 012
- The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "HEAL Initiative: HEAL KIDS (Knowledge, Innovation and Discovery Studies) Pain Program Resource and Data Center (U24 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.213, 93.233, 93.273, 93.361, 93.837, 93.838, 93.839, 93.840, 93.846, 93.853, 93.865, 93.866.
- This funding opportunity was created on 2023-08-18.
- Applicants must submit their applications by 2023-11-20. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: HEAL Initiative - HEAL KIDS Pain Program Resource and Data Center (RDC) (RFA-HD-24-012)
What is this funding opportunity?
This opportunity (RFA-HD-24-012) is an NIH cooperative agreement (U24; clinical trial not allowed) to establish a single HEAL KIDS Pain Program Resource and Data Center (RDC). The RDC is intended to function as a centralized coordinating hub that supports the broader HEAL KIDS Pain research program by standardizing, organizing, and streamlining data and shared resources across the program.
What is the HEAL Initiative and how does HEAL KIDS fit into it?
The RDC sits under the NIH Helping to End Addiction Long-term (HEAL) Initiative. HEAL KIDS (Knowledge, Innovation and Discovery Studies) is a pediatric-focused effort within HEAL, and this RDC is designed to support HEAL KIDS Pain research activities by providing shared program infrastructure, especially around data and resource coordination.
Which NIH Institute is leading this opportunity?
The opportunity is led by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), along with other participating NIH Institutes and Centers, reflecting the multi-institute nature of the HEAL Initiative.
What is the main purpose of the RDC?
The main purpose is to create one centralized, program-wide resource that supports HEAL KIDS Pain studies with consistent data practices and infrastructure. Rather than funding multiple separate data centers, NIH intends to make a single award for one RDC that can support the entire program.
Is NIH planning to fund multiple data centers?
No. Based on the provided information, NIH intends to fund a single RDC. The concept is to avoid multiple separate data centers and instead create one centralized coordinating hub for the full HEAL KIDS Pain program.
What award mechanism is being used?
The mechanism is a U24 cooperative agreement. A cooperative agreement indicates that NIH will have substantial involvement in the award, meaning the funded RDC will be expected to coordinate closely with NIH program staff on deliverables, timelines, and governance.
Are clinical trials allowed under this RDC award?
No. The RDC funding opportunity is explicitly labeled "clinical trial not allowed." The RDC is intended to enable and coordinate research (especially data and resources) rather than conduct interventional clinical trials.
How does this RDC relate to the companion opportunity (RFA-HD-24-011)?
This RDC NOFO is designed to run in parallel with a companion opportunity (RFA-HD-24-011) that supports innovative, multi-site, large-scale clinical trials focused on acute pain in infants, children, and adolescents. The RDC is meant to serve as the backbone that supports consistent data practices and shared tools across those trials and other HEAL KIDS Pain research activities.
If RFA-HD-24-011 supports clinical trials, why is the RDC "clinical trial not allowed"?
The clinical trials are supported under the companion NOFO (RFA-HD-24-011). In contrast, RFA-HD-24-012 funds the infrastructure center (the RDC) whose role is to support and coordinate the research ecosystem, particularly around data collection, harmonization, standards, and resource coordination, not to run interventional trials itself.
What core data functions is the RDC expected to provide?
The RDC is expected to provide leadership and hands-on infrastructure for tightly connected functions, including:
- Data collection and management (systems, workflows, and quality oversight)
- Data curation (cleaning, documentation, and preparation for reuse)
- Data harmonization (aligning variables and formats across sites and studies)
- Data standards development and implementation (common data elements, naming conventions, metadata requirements, and consistent definitions)
What does "data harmonization" mean in this context?
In this context, data harmonization refers to aligning variables, formats, and definitions across different sites and studies so that information can be compared and combined more easily across the HEAL KIDS Pain program.
What does "data curation" mean in this context?
In this context, data curation involves cleaning data, documenting it, and preparing it for reuse, which supports higher-quality datasets that can be used for future analyses and shared program needs.
Will the RDC set data standards for the program?
Yes. The RDC is expected to develop and implement data standards, including common data elements, naming conventions, metadata requirements, and consistent definitions to promote standardization across HEAL KIDS Pain studies.
Beyond data, what other responsibilities does the RDC have?
In addition to technical data responsibilities, the RDC is tasked with administrative and logistical coordination for HEAL KIDS Pain activities. This includes coordinating shared research-related resources and helping ensure compliance with NIH HEAL-related expectations.
What does NIH "substantial involvement" mean for applicants?
Because this is a U24 cooperative agreement, NIH will be actively involved. The RDC will be expected to work closely with NIH program staff and align governance, timelines, and deliverables with NIH direction as the program operates.
Who is eligible to apply?
Eligibility is broad for domestic U.S. organizations and includes (as provided):
- State, county, and local governments
- Special district governments
- Independent school districts
- Public and private institutions of higher education
- Federally recognized tribal governments
- Tribal organizations other than federally recognized governments
- Public housing authorities/Indian housing authorities
- Nonprofits with and without 501(c)(3) status (other than institutions of higher education)
- For-profit organizations (other than small businesses)
- Small businesses
- Other eligible entities
- U.S. territories or possessions
Are any specific institution types explicitly called out as eligible?
Yes. The announcement also calls out eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, HBCUs, TCCUs, faith-based or community-based organizations, regional organizations, eligible federal agencies, and Indian/Native American tribal governments other than federally recognized entities (as applicable).
Are foreign organizations eligible to apply?
No. Non-domestic (non-U.S.) entities (foreign organizations/institutions) are not eligible to apply.
Can a U.S. organization apply if part of the work will be done by a non-U.S. component?
No. Non-domestic components of U.S. organizations are not eligible to apply, and foreign components (as defined by NIH in the NIH Grants Policy Statement) are not allowed.
Which federal agency is sponsoring this opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
What type of funding is this considered?
It is categorized as discretionary funding and uses a cooperative agreement mechanism, reflecting NIH's active partnership role.
What is the listed closing date?
The original closing date listed in the provided information is 2023-11-20.
Is the award ceiling provided?
No. The award ceiling is not specified in the provided source text.
How many awards does NIH expect to make?
The expected number of awards is not specified as a numeric value in the provided text, but the narrative indicates NIH intends to fund a single RDC.
Which CFDA numbers are associated with this opportunity?
The opportunity references multiple CFDA numbers associated with NIH programs: 93.121, 93.213, 93.233, 93.273, 93.361, 93.837, 93.838, 93.839, 93.840, 93.846, 93.853, 93.865, 93.866. This reflects the multi-institute nature of HEAL-related funding streams.
What kinds of studies is the broader HEAL KIDS Pain program focused on?
Based on the companion opportunity description, the broader program includes innovative, multi-site, large-scale clinical trials focused on acute pain in infants, children, and adolescents, including populations with disabilities and/or those experiencing health disparities. The RDC supports the program by enabling consistent data practices and shared resources.
What is the expected impact of creating a single RDC?
The expected impact includes improved standardization and interoperability across pediatric pain research efforts within HEAL, easier cross-study comparability, accelerated secondary analyses, reduced duplication of effort at individual sites, and stronger compliance with HEAL and NIH data expectations.
What is the core "problem" this RDC is meant to solve?
The RDC is designed to address fragmentation that can occur when multiple studies collect and manage data differently. By providing shared standards, harmonization, and coordinated data infrastructure, the program can more easily combine and compare data across studies and sites.
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