Opportunity Information: Apply for RFA HD 24 012

The HEAL Initiative: HEAL KIDS (Knowledge, Innovation and Discovery Studies) Pain Program Resource and Data Center (RDC) funding opportunity (RFA-HD-24-012) is an NIH cooperative agreement (U24; clinical trial not allowed) designed to establish one centralized coordinating hub to support the broader HEAL KIDS Pain research program. It sits under the NIH Helping to End Addiction Long-term (HEAL) Initiative and is led by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) along with other participating NIH Institutes and Centers. The core idea is that, rather than funding multiple separate data centers, NIH intends to make a single award to an RDC that can standardize, organize, and streamline how HEAL KIDS Pain studies collect, manage, harmonize, and share data and related resources across the entire program.

The RDC is expected to provide leadership and hands-on infrastructure for several tightly connected functions: data collection and management (including systems, workflows, and quality oversight), data curation (cleaning, documentation, and preparation for reuse), data harmonization (aligning variables and formats across different sites and studies), and the development and implementation of data standards (common data elements, naming conventions, metadata requirements, and consistent definitions). In addition to these technical data responsibilities, the RDC is also tasked with administrative and logistical coordination for HEAL KIDS Pain activities, including helping ensure compliance with NIH HEAL-related expectations and coordinating shared research-related resources that multiple projects will rely on. Because this is a U24 cooperative agreement, the NIH will have substantial involvement, meaning the RDC will be expected to work closely with NIH program staff and align deliverables, timelines, and governance with NIH direction.

This NOFO is designed to run in parallel with a companion opportunity (RFA-HD-24-011) that funds innovative, multi-site, large-scale clinical trials focused on acute pain in infants, children, and adolescents, including populations with disabilities and/or those experiencing health disparities. In practice, that means the RDC is meant to be the backbone that enables those clinical trial sites and other HEAL KIDS Pain research activities to operate on a shared set of data practices and tools, making it easier to combine information across studies, improve comparability, and accelerate secondary analyses. Even though the companion NOFO supports clinical trials, the RDC award itself is explicitly "clinical trial not allowed," signaling that the center should not be running interventional trials; instead, it should focus on enabling and coordinating the research ecosystem, especially on the data and resource side.

Eligibility is broad and includes many domestic U.S. organization types: state, county, and local governments; special district governments; independent school districts; public and private institutions of higher education; federally recognized tribal governments; tribal organizations other than federally recognized governments; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); small businesses; and other eligible entities. The announcement also calls out additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, Indian/Native American tribal governments other than federally recognized entities (as applicable), and U.S. territories or possessions. At the same time, the NOFO clearly limits foreign involvement: non-domestic (non-U.S.) entities (foreign organizations/institutions) are not eligible to apply; non-domestic components of U.S. organizations are not eligible to apply; and foreign components, as NIH defines them in the NIH Grants Policy Statement, are not allowed.

Administratively, the sponsoring agency is the National Institutes of Health, and the opportunity is categorized under discretionary funding, using the cooperative agreement mechanism to reflect NIH's active partnership role. The original closing date listed is 2023-11-20. The opportunity references multiple CFDA numbers associated with NIH programs (93.121, 93.213, 93.233, 93.273, 93.361, 93.837, 93.838, 93.839, 93.840, 93.846, 93.853, 93.865, 93.866), reflecting the multi-institute nature of HEAL-related funding streams. The award ceiling and expected number of awards are not specified in the provided source text, but the narrative states NIH intends to fund a single RDC, emphasizing that this is meant to be one central, program-wide resource rather than multiple competing centers.

Taken together, the RDC opportunity is essentially a program infrastructure award: it is meant to create the shared data environment, rules, coordination processes, and operational support that allow HEAL KIDS Pain studies, including the companion multi-site clinical trials, to generate consistent, high-quality, reusable data. The expected impact is improved standardization and interoperability across pediatric pain research efforts within HEAL, faster cross-study learning, reduced duplication of effort at individual sites, and stronger compliance with HEAL and NIH data expectations.

  • The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "HEAL Initiative: HEAL KIDS (Knowledge, Innovation and Discovery Studies) Pain Program Resource and Data Center (U24 Clinical Trial Not Allowed)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.213, 93.233, 93.273, 93.361, 93.837, 93.838, 93.839, 93.840, 93.846, 93.853, 93.865, 93.866.
  • This funding opportunity was created on 2023-08-18.
  • Applicants must submit their applications by 2023-11-20. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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