Opportunity Information: Apply for RFA MH 20 341
The National Institute of Mental Health (NIMH), within the U.S. Department of Health and Human Services (HHS) and the National Institutes of Health (NIH), released this discretionary funding opportunity to establish a single Data Processing, Analysis, Data Management, and Coordinating Center focused on Clinical High Risk (CHR) for psychosis. The opportunity is issued as a cooperative agreement using the U24 activity code, which signals that the funded center would work closely with NIMH staff in an ongoing, collaborative partnership rather than operating as a fully independent, investigator-directed research project. The FOA is explicitly marked "Clinical Trial Not Allowed," meaning the funded work is intended to support data infrastructure, harmonization, and coordination functions rather than initiating or running interventional clinical trials.
The core purpose of the award is to create a centralized hub (referred to in the announcement as a DACDPACC) that can aggregate, manage, and analyze existing CHR-related datasets. In practical terms, this kind of center is typically responsible for building the technical and governance backbone needed to combine data across multiple studies or sites, improve data quality and consistency, and enable large-scale analyses that would be difficult for individual research groups to conduct alone. Because CHR research often involves diverse clinical assessments, neurocognitive measures, imaging, genetics, and longitudinal outcomes, a dedicated data center can play a major role in harmonizing variables, establishing common data elements, developing data dictionaries, handling secure storage and access controls, and setting up reproducible analysis pipelines so results can be compared and replicated across networks.
A second major aim is network oversight and coordination for CHR research networks that NIMH planned to fund under a separate, future FOA referenced as NOT-MH-19-042. The center described here is meant to serve as the organizing and coordinating backbone for those networks once they are launched. That coordination role typically includes creating and maintaining communication and reporting structures, supporting multi-site governance (for example, steering committees and working groups), tracking study progress and milestones, aligning procedures and documentation across projects, and ensuring consistent approaches to data submission, quality assurance, and analytical standards. In other words, the award is designed to make sure the broader CHR research ecosystem can function as a cohesive, interoperable network rather than as isolated projects using incompatible methods and datasets.
From an administrative standpoint, the FOA (RFA MH 20 341) was posted with an original closing date of January 31, 2020, and an NIH creation date of November 27, 2019. Only one award was expected, which is consistent with the idea of a single coordinating center serving as the shared resource for multiple research efforts. The listing shows an award ceiling of "0," which generally indicates the ceiling was not specified in the summary field rather than implying no funding; applicants usually need to consult the full FOA text for budget guidance, allowable costs, and project period expectations.
Eligibility is broad and includes a wide range of U.S.-based entities capable of building and running a complex data and coordinating center. Eligible applicants include federal, state, county, city, township, and special district governments; public and private institutions of higher education; independent school districts; Native American tribal governments and organizations; public housing authorities; nonprofit organizations with and without 501(c)(3) status; for-profit organizations (including small businesses); and other organizations as allowed under the FOA's additional eligibility language. This broad eligibility aligns with the technical and operational nature of the work, since strong candidates may come from academic data coordinating centers, nonprofit research institutes, health systems with mature informatics infrastructure, or specialized private-sector groups with deep experience in secure data platforms and multi-site coordination.
Overall, the opportunity is best understood as an infrastructure and coordination investment aimed at accelerating CHR for psychosis research by bringing existing data together, making it more usable and comparable, and creating a centralized operational backbone for upcoming NIMH-funded CHR networks. The emphasis is on data processing, analysis, data management, and coordination rather than running new clinical interventions, with NIMH playing an active role through the cooperative agreement mechanism to ensure the center meets network-wide needs and supports high-quality, scalable, collaborative science.Apply for RFA MH 20 341
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Clinical High Risk for Psychosis: Data Processing, Analysis, and Coordination Center (U24 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242.
- This funding opportunity was created on Nov 27, 2019.
- Applicants must submit their applications by Jan 31, 2020. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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