Opportunity Information: Apply for RFA CA 24 005
Cancer Prevention, Detection, Diagnosis, and Treatment Technologies for Global Health (U01 Clinical Trial Optional) is a National Institutes of Health, National Cancer Institute funding opportunity (RFA-CA-24-005) that aims to move practical cancer technologies closer to real-world use in low- and middle-income countries (LMICs). The focus is on turning an existing or emerging assay, device, or treatment-enabling technology into a user-friendly, low-cost solution that can realistically function in LMIC clinical and community settings. Rather than funding early concept exploration, this announcement expects applicants to begin with a working prototype or assay platform (it does not have to be originally designed for cancer) and then adapt it to a clearly defined cancer prevention, detection, diagnosis, or treatment use case relevant to LMIC needs.
The award mechanism is a U01 cooperative agreement, which generally means NIH staff will have substantial scientific and programmatic involvement during the project, and the work is expected to be milestone-driven. Projects are expected to show more than incremental engineering: teams must demonstrate technical functionality and clinical performance for the proposed LMIC context, using objective performance milestones. The FOA emphasizes an iterative pathway where the technology is adapted, tested, improved, and validated in the settings where it is intended to be deployed, rather than being developed exclusively in high-resource environments and only later introduced abroad. Clinical trials are optional, so proposals may include clinical evaluation when appropriate, but they are not mandatory for every project.
A defining theme is implementation realism. Applicants are expected to treat affordability, cost-effectiveness, and usability at the point-of-need as core design requirements, not afterthoughts. That includes designing for constraints common in LMIC environments, such as limited infrastructure, variable power and connectivity, constrained supply chains, limited specialist availability, and the need for robust performance under real-world conditions. The intended output is a new generation of practical, scalable cancer technologies that can be used where the cancer burden is high and resources are limited.
Because success requires more than technical performance, the FOA requires multidisciplinary teams. Every application team must include expertise spanning (1) engineering, assay development, or treatment technology development, (2) oncology, (3) global health care delivery (people who understand how care is actually delivered in LMIC systems), and (4) business development. The business development requirement signals that applicants should plan for pathways to manufacturing, distribution, servicing, regulatory strategy where relevant, adoption, and sustainability. In other words, the program is looking for technologies with a credible route to deployment and long-term use, not just promising lab results.
This opportunity sits within the NCI Affordable Cancer Technologies (ACTs) Program, which broadly targets cancer technology innovation that is cost-conscious and appropriate for lower-resource settings. The activity categories listed include education and health, and the CFDA numbers associated with the program are 93.394 and 93.395. While the scientific content centers on technology development and validation, the program framing reinforces that the end goal is improved cancer outcomes through tools that can be integrated into real care pathways in LMICs.
Eligibility is broad and includes many types of U.S.-based and non-U.S. organizations. Eligible applicants include state, county, city, township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); and small businesses. The FOA also explicitly calls out additional eligible applicant categories such as historically black colleges and universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, Asian American and Native American Pacific Islander serving institutions (AANAPISISs), faith-based or community-based organizations, eligible federal agencies, U.S. territories or possessions, regional organizations, and non-domestic entities (foreign organizations). This breadth aligns with the program goal of encouraging partnerships that combine technical innovation with on-the-ground LMIC experience and deployment capability.
Key administrative details from the posted source include an original closing date of 2023-10-13, an award ceiling listed at $475,000, and the funding instrument type as a cooperative agreement. Overall, the FOA is best read as a targeted push to translate a functioning prototype into a validated, field-ready cancer technology for LMIC use, with clear expectations around milestones, multidisciplinary collaboration, and design choices driven by cost, usability, and delivery realities.Apply for RFA CA 24 005
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Cancer Prevention, Detection, Diagnosis, and Treatment Technologies for Global Health (U01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.394, 93.395.
- This funding opportunity was created on 2023-04-20.
- Applicants must submit their applications by 2023-10-13. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $475,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| Emergency Medicine Research Career Development Program in the Neurological Sciences (EMRCDP-NS) (K12 - No Independent Clinical Trial Allowed) Apply for PAR 23 151 Funding Number: PAR 23 151 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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| Field-Deployable, Low-Cost Point-of-Need Approaches and Technologies to Lower the Barriers to Substance Use Disorders (SUD) Diagnosis and Treatment (R43/R44 Clinical Trial Optional) Apply for RFA DA 24 018 Funding Number: RFA DA 24 018 Agency: National Institutes of Health Category: Education, Health Funding Amount: $295,924 |
| Field-Deployable, Low-Cost Point-of-Need Approaches and Technologies to Lower the Barriers to Substance Use Disorders (SUD) Diagnosis and Treatment (R41/R42 Clinical Trial Optional) Apply for RFA DA 24 017 Funding Number: RFA DA 24 017 Agency: National Institutes of Health Category: Education, Health Funding Amount: $295,924 |
| Accelerating Behavioral and Social Science through Ontology Development and Use: Research Network Projects (U01 Clinical Trial Not Allowed) Apply for PAR 23 182 Funding Number: PAR 23 182 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
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| Leveraging Social Networks to Promote Widespread Individual Behavior Change (R34 Clinical Trial Optional) Apply for RFA AG 24 026 Funding Number: RFA AG 24 026 Agency: National Institutes of Health Category: Education, Health Funding Amount: $225,000 |
| NIH Neuroscience Development for Advancing the Careers of a Diverse Research Workforce (R25 Clinical Trial Not Allowed) Apply for PAR 23 178 Funding Number: PAR 23 178 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Substance Use/Substance Use Disorder Dissertation Research Award (R36 Clinical Trials Not Allowed) Apply for PAR 23 194 Funding Number: PAR 23 194 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| The Blood and Marrow Transplant Clinical Trials Network - Data Coordinating Center (U24 Clinical Trial Not Allowed) Apply for RFA HL 24 011 Funding Number: RFA HL 24 011 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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